Abstract
Organic Chemistry Most organic compounds contain numerous carbon-hydrogen (C–H) bonds. The weakest among them are easy to transform selectively, but the stronger ones tend to be hard to discriminate. Zhao et al. report a manganese catalyst that can selectively oxidize CH2 centers in the presence of aromatic C–H bonds. The catalyst activates hydrogen peroxide with the help of chloroacetic acid, and despite targeting strong C–H bonds, it tolerates halogen, oxygen, and nitrogen functionality. The protocol is demonstrated across a variety of pharmaceutically relevant compounds. Nat. Chem. 10.1038/s41557-018-0175-8 (2018).
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