Abstract
The management of high-risk and relapsed/refractory (R/R) MM patients remain a therapeutic challenge as outcomes remain poor. The most part of these patients ultimately become refractory to treatment, due in part to a lack of a successful mechanism-based therapies and genetic instability with numeric chromosomal abnormalities. Aurora kinase B (AURKB) is a key regulator of mitosis as a component of the chromosomal passenger complex (CPC). The CPC has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly as well as orderly cytokinesis.
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