Abstract
Tumor-related angiogenesis is a complex process resulting from a delicate balance between pro and anti-angiogenic factors. Bevacizumab, a fully humanized monoclonal antibody against vascular endothelial growth factor (VEGF), was the first anti-angiogenic therapy to prove effective, in combination with chemotherapy, for treatment of several types of advanced cancer, non-small-cell lung cancer (NSCLC) included. However, as for other types of solid malignancy, no predictive biomarkers of increased sensitivity to bevacizumab or any other anti-angiogenic drugs could be identified in NSCLC, which has had a negative affect on the cost-effectiveness of the targeted therapy performed to block the VEGF pathway. In this review we discuss the most relevant findings from clinical and correlative studies investigating the use of anti-angiogenic therapy for advanced NSCLC, focusing on the need to identify biomarkers for selection of patients suitable for anti-angiogenic therapy.
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