Targeting a common eye cancer

Abstract

Cancer Signaling Uveal melanoma is a common cancer of the eye that frequently metastasizes. Most cases of uveal melanoma are driven by constitutively active mutants of the G protein α subunits Gαq and Gα11; however, therapies that target signaling pathways downstream of these oncogenic drivers have been unsuccessful. Annala et al. confirmed that the plant-derived compound FR900359 directly inhibits oncogenic Gαq/11 signaling in uveal melanoma cell lines in vitro. Furthermore, FR900359 reduced mutant Gαq–driven uveal melanoma tumor growth in a mouse xenograft model. Sci. Signal. 12 , eaau5948 (2019).