Abstract
Soft tissue sarcomas are an uncommon and diverse group of more than 50 mesenchymal malignancies with very specific underlying molecular events driving oncogenesis. The mysterious pathogenesis is slowly revealing the vary secrets of their inner workings. There is a paradigm shift in sarcoma management wherein therapeutic decisionmaking is guided by key genetic events of oncogenic potential. Present perspective, will focus on the rationale for targeted delivery of therapy in sarcoma, with emphasis on the relevance of specific molecular factors and pathways. It will also focus upon the story behind some of the early successes and challenges and disappointments in taming these targets. Finally it will discuss possible opportunities represented by poorly understood, but potentially promising new therapeutic targets and investigational biological agents. This communication will provide a demarche of the current state of the art for medical management of sarcomas and a sense of where it may be headed in the coming years.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
