Targeted Temperature Management Following Out-of-Hospital Cardiac Arrest: Integrating Evidence into Real World Practice.

Abstract

Targeted temperature management (TTM) post-out of hospital cardiac arrest (OHCA) has been a focus of debate in an attempt to improve post-arrest outcomes. Contemporary trials examining the role of TTM post-cardiac arrest suggest that targeting normothermia should be the standard of care for initially comatose survivors of cardiac arrest. Differences in patient populations have been demonstrated across trials and important subgroups may be under-represented in clinical trials compared to real-world registries. In this review, we aimed to describe the populations represented in international OHCA registries and to propose a pathway to integrate clinical trial evidence into practice. The patient case-mix among registries including survivors to hospital admission was similar compared to the pivotal trials (shockable rhythm, witnessed arrest), suggesting reasonable external validity. Therefore, for the majority of OHCA, targeted normothermia should be the strategy of choice. There remains conflicting evidence for patients with a non-shockable rhythm with no clear evidence-based justification for mild hypothermia over targeted normothermia.