Targeted Sequencing of Genes Most Likely to Harbor Rare Causal Variants in Schizophrenia

Abstract

Though whole-exome sequencing (WES) studies have begun to show promise in identifying schizophrenia (SCZ) risk genes that harbor rare causal variants, they remain largely underpowered due in part to high sequencing costs. To circumvent this issue, we leveraged results from the largest SCZ WES study to date and designed a targeted sequencing panel comprising the genes most likely to impact SCZ risk.