Abstract
A challenge for nanomedicine is to improve their targeting ability and avoid nonspecific interactions with the surrounding environments. Herein, we report the fabrication of photosensitizer-loaded poly(ethylene glycol) nanoparticles (PEG NPs) with high targeting ability to inhibit cancer cell growth. PEG NPs are prepared via a mesoporous silica (MS) templating method and functionalized with cyclic Arg-Gly-Asp (RGD) peptides for specific targeting to U87 MG cells expressed with αvβ3 integrins. Chlorin e6 (Ce6) as a photosensitizer is conjugated onto PEG and encapsulated into PEG NPs for photodynamic therapy (PDT). The obtained PEG-Ce6-RGD NPs can efficiently target to U87 MG cells and improve the PDT efficacy. Our approach provides an avenue to engineer targeted polymer carriers for PDT.
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