Abstract
Background: Targeted UVB phototherapy currently ranks among the most effective treatment options in localized vitiligo. Purpose: The study aims to assess the efficacy of Targeted NBUVB monotherapy in childhood vitiligo involving less than 10% body surface area. Methods: Thirty-five children with vitiligo, less than 15-years of age were treated with Targeted NBUVB device twice weekly till complete resolution of the treated lesions or till maximum of 30 doses whichever occurred earlier. The extent of re-pigmentation achieved was assessed on the basis of VASI scoring system and was graded as excellent (>75% re-pigmentation), good (50-75% re-pigmentation) or poor ( 75% repigmentation. Among the rest, 33 lesions (28.9%) failed to show a satisfactory response to treatment while 20 lesions (17.5%) showed a good response in the form of 50-75% repigmentation. Lesions on face and neck responded the best to the treatment regimen. Conclusions: Targeted NBUVB therapy is a promising therapy in childhood vitiligo where the disease involves <10% body surface area.
Highlights
Vitiligo is an acquired disorder of melanin pigmentation that affects about 1% of the world population [1]
Targeted NBUVB therapy is a promising therapy in childhood vitiligo where the disease involves
Phototherapy with NBUVB has emerged as one of the most favoured treatment options in vitiligo. This treatment option has been found to be effective in both adult as well as childhood vitiligo with no significant adverse effects [4,5]
Summary
Vitiligo is an acquired disorder of melanin pigmentation that affects about 1% of the world population [1]. Even combination therapies of NBUVB with topical and oral agents have been described with possible synergistic effects [6,7,8] Targeted phototherapy is another advancement in this field wherein the phototherapeutic device ‘targets’ the lesional skin while the rest of skin remains unexposed. Targeted UV light-based therapies employ conventional noncoherent ultraviolet light that is delivered through fibre-optic cable systems to the treatment area. These machines deliver the light energy in seconds and have larger spot sizes [14,15,16,17]. Purpose: The study aims to assess the efficacy of Targeted NBUVB monotherapy in childhood vitiligo involving less than 10% body surface area
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