Targeted Exome Resequencing: Adme Pharmacogenetics In Human Liver

Abstract

August 2015 e71 Stevens-Johnson Syndrome, toxic epidermal necrolysis (SJS/TEN), DRESS (drug reaction with eosinophilia and systemic symptoms), and acute generalized exanthematous pustulosis (AGEP). Objective: To identify serious cases of (CADR) and the main suspected drugs. Materials and Methods: Retrospective observational, between 2008 and 2014 at the Clinical Pharmacology Service of Hospital Universitario de la Princesa (Madrid) have identified 28 cases of severe skin reactions induced by drugs. Results: Twenty-eight (CADR), 18 women and 10 men, mean age 43.1 years, (35.7%) in dermatology services, UCI, internal medicine. The main identified toxicodermia was AGEP (35.71%), followed by DRESS syndrome and SJS / TEN (25%), erythema multiforme (7.14%), leukocytoclastic vasculitis and linear IgA bullous dermatitis (3.57%). Main identified drug was phenytoin (28.75%), followed by amoxicillin/clavulanate (14.28%), carbapenems, antiretroviral treatment, piperacillin/tazobactam and magnesium metamizol (7.14%), and allopurinol, tramadol, NSAIDs, vancomycin, clindamycin, ranitidine, and simvastatin a (3.57%). Mortality rate was: 28.57% (n = 8), of which 4 by SJS/TEN, 2 by DRESS, and 2 by AGEP total of 8 patients. Conclusions: Serious toxicodermies in the Hospital de la Princesa have a low frequency but are associated with high mortality, risk of complications and sequelae; Very similar to that found in other studies, the most frequent is acute generalized exanthematous pustulosis.