Abstract
Targeted Endometrial Scratching: An Example of Endometrial Diagnosis Usage in Reproductive Medicine
Highlights
Over the last ten years, debates regarding the potential benefit of an endometrial scratching to enhance embryo implantation have been continuous
As suggested by these studies, selected endometrial cytokines or immune cells could be considered as relevant candidates to become the biomarkers of the local immune activation or inflammation, for example the endometrial cytokine levels (MIP-1B, IL-15, TNF, VEGF) or the endometrial immune cell recruitment (DCs, macrophages, uterine Natural Killer cells (uNK))
Timed immune changes in the human endometrium are crucial for embryo implantation
Summary
Over the last ten years, debates regarding the potential benefit of an endometrial scratching to enhance embryo implantation have been continuous. Majority of reports on endometrial scratching do not use any endometrial diagnostic tool beforehand to confirm the actual need to enhance the local inflammation. In this manuscript, we will first focus on the immune rationale linking endometrial inflammation and embryo implantation, the potential biomarkers of endometrial inflammation, as well as the local effects of an endometrial scratching. In the 80’s, researchers documented the association of mechanical manipulation with decidual formation in rodents [1, 2] and used this system to trigger the endometrial decidualization of foster mothers in case of embryo transfer By analogy, they started to explore the effect of a local injury in human endometrium
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