Targeted Delivery of Apoptotic Cell‐Derived Nanovesicles prevents Cardiac Remodeling and Attenuates Cardiac Function Exacerbation (Adv. Funct. Mater. 23/2023)

Abstract

Apoptotic Bodies In article number 2210864, Yoon Ki Joung, Bong-Woo Park, and co-workers report apoptotic cell-derived nanovesicles (ApoNVs) decorated with targeting molecules that can be actively delivered to ischemic myocardium for myocardial infarction treatment. By the surface modification of ApoNVs, macrophages in the infarcted myocardium selectively uptake ApoNVs and subsequently exhibit anti-inflammatory phenotype, which successfully results in the cardiac function improvement.