Targeted α-Based Treatment of Metastatic Castration-Resistant Prostate Cancer: Revolutionizing Systemic Radiotherapy?

Abstract

1838 Objectives In this study, we aimed to first cross-validate the reproducibility of disease-specific brain networks and metabolic activity associated with progressive supranuclear palsy (PSP) by comparing clinically-confirmed patients in the USA and China. Methods The US cohort of 10 patients with PSP and 10 age-matched healthy controls was scanned on a GE Advance PET camera. The Chinese cohort of the same sample size was scanned on a Siemens Biogragh PET/CT system in China. We first identified a PSP-related pattern (PSPRP) in each cohort and computed network scores prospectively in the other cohort. We then localized brain regions with common or different metabolic abnormalities in the same data using statistical parametric mapping analysis. Results Both cohorts produced analogous PSPRPs characterized by metabolic decreases in the middle prefrontal cortex/cingulate, ventrolateral prefrontal cortex, striatum, thalamus and midbrain, covarying with metabolic increases in the hippocampus and parieto-temporal regions. PSPRP scores were similarly elevated (P < 0.0001; post-hoc tests following one-way analysis of variance across the two cohorts) in the patients relative to the controls in the derivation cohort in the USA and in the validation cohort in China or vice versa. PSPRP scores of each pattern correlated strongly (r 蠅 0.96; P < 0.001) in the two corresponding cohorts from the USA and China, respectively. Moreover, the two cohorts of patients shared a large number of overlapping areas with regional metabolic abnormalities (P < 0.0001) in the same cortical and subcortical regions as in both PSPRPs. Conclusions This dual-center collaborative study demonstrated the high comparability and reproducibility of PSP-related metabolic activities at network and regional levels across patient populations, PET instruments and analytical techniques. These results suggest that metabolic brain network activity may serve as a reliable and objective marker of PSP and is worthy of wide applications in clinical diagnosis and translational research.