Abstract
Background: In the UNLOAD trial, ultrafiltration (UF) removed volume more effectively than usual care (UC). Hypothetically, UF may be superior to UC due to more sodium (Na) removal and less neurohormonal activation. We compared UF and UC in a randomized pilot trial of target weight guided therapy for acute heart failure (AHF). Methods: Sixteen patients with AHF were enrolled and target weights established prospectively, prior to randomization to UF or UC. UF patients did not receive diuretics and UC patients all treated with a furosemide drip.
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