Target Temperature Management Versus Normal Temperature Management for Cardiac Arrest After Traumatic Brain Injury Patient: A Meta-Analysis and Systemic Review.

Abstract

This study compares the treatment outcomes between target temperature management (TTM) and normal temperature management (NTM) for cardiac arrest after traumatic brain injury (TBI). Two reviewers searched PubMed/MEDLINE, China National Infrastructure database for studies reporting on the use of TTM and NTM. All publications from inception to October 2021 were considered. Randomized control trials (RCTs) with cardiac arrest after TBI diagnoses were made based on the 2019 American Stroke Association (ASA) guidelines,1 wherein the included cardiac arrest patients underwent TTM or NTM treatment were included in this study. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommended tool was used for assessing the risk of bias of the included RCTs. In all, 1920 publications were identified. However, after applying the inclusion and exclusion criteria, 6 RCTs, including 1617 patients who received TTMs (n = 826) and NTMs (n = 791), were considered eligible. The meta-analysis indicated that compared with NTM, TTM did not show a decrease in the mortality, however, for those mild patients in the early stage, TTM still can decrease the mortality and better the prognosis. Compared with NTM, TTM is an effective measure to treat mild and severe patients in the early stage and improve the prognosis.