Abstract
The novel chemical framework and potent antitumor activity of the enediyne natural products such as calicheamicin, dynemicin, esperamicin, and neocarzinostatin has fostered interest in the development of simple enediynes with low thermal cyclization temperature. It is well established that thermally labial enediynes exhibit anticancer activity, while there are few scattered examples in the literature about the biological importance of thermally stable enediynes. The present article deals with the synthesis, thermal reactivity of metalloenediynes, and antibacterial activity of thermally stable cyclic enediynes.
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