Target controlled infusion of Propofol with Remifentanil or Sufentanil for anesthesia with la-ryngeal mask airway ventilation

Abstract

Objective To evaluate the influence of Remifentanil and Sufentanil on effect of Propofol anesthesia with laryngeal mask airway ventilation. Methods Sixty patients scheduled for elective surgery were randomly divided into propofol group ( group P, n=20 ), propofol with remifentanil group ( group PR, n=20 ) and propofol with sufentanil group ( group PS, n=20 ) .The patients were anesthetized with target controlled infusion of Propofol and RemifentaniK 4 ng/ml) or Sufentanil ( 0.5 ng/ml ).The initial target plasma concentration of Propofol was 2 μ g/ml, and increased step by step until loss of consciousness.The hemodynamic changes and the dosage of Propofol and recovery of anesthesia were observed in all patients.Results Blood pressure was significantly lower in all groups,and HR decreased in PR group after induction of anesthesia(P<0.05 ).Systolic and diastolic blood pressure increased significantly after laryngeal mask airway insertion in group P.The dosage of Propofol required for maintenance of anesthesia in group PR and group PS were reduced by 32.7% and 35.5% respectively.ET-CO2 by spontaneously breathing was higher in the PS group than in group P and group PR when the patients opened their eyes.The times from drug withdrawal to ET-C02 drop to 45mmHg by spontaneously breathing were longer in the PS group than in group P and group PR.Conclusions Remifentanil and sufentanil can reduce significantly the dosage of propofol for anesthesia with laryngeal mask airway ventilation, inhibit the hemodynamic responses to laryngeal mask airway insertion.But the times of laryngeal mask airway extubation could be prolonged by sufentanil during the revitalization of anesthesia. Key words: Propofol; Remifentanil; Sufentanil; Target controlled infusion; Laryngeal mask airway