Target-Conformal Optimization-Based Actuator Placement for Ultrasound-Mediated Hyperthermia in Cancer Treatments

Abstract

In hyperthermia for cancer treatments, tumors are heated to improve the outcome of radio-and chemotherapies. Using extracorporeal high-intensity focused ultrasound (HIFU) transducers, the heating can be applied noninvasively, accurately, and with high acoustic power. The heating location can be changed by electronic beam steering, within the transducer’s small local heating range, and by mechanically repositioning the transducer, which effectively shifts the local range to enable the treatment of larger tumors. An important problem is the selection of the sonication points, i.e., the discrete locations reachable by electronic beam steering, and the admissible mechanical transducer positions, which must be performed prior to treatment, and can be seen as an actuator selection problem. Clearly, the selected sonication points and transducer positions have a major impact on the achievable tumor temperatures, and their number is directly related to the controller’s complexity and, thereby, real-time feasibility. To address this challenging problem, this brief presents a target-conformal optimization-based actuator placement procedure, designed to assist the clinician in enabling maximum treatment quality using only a limited number of sonication points and transducer positions. The method is computationally tractable, and takes into account the specific tumor geometry and tissue properties.