Abstract
Base-Pair Mismatch In article 2202076, Yoon Sung Nam and co-workers develop a new miRNA detection platform based on miRNA-catalyzed toehold-mediated strand displacement and the sequential formation of DNA-streptavidin nanogel. The detection limit is lowered from the nanomolar level to the picomolar level by introducing a single base-pair mismatch near the toehold enhancing strand displacement and generating a 3D nanogel network to facilitate Förster resonance energy transfer.
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