Abstract
Because of its potential applications in the understanding of membrane function, high resolution in situ imaging by AFM of the surface of cells in their aqueous medium remains an important goal. Based on two examples, the in situ imaging of detergent-resistant plasma membrane domains and of the lateral membrane of outer hair cells from the inner ear, we show that low-force tapping mode AFM allows the access to the topography of very fragile membrane structures and that details of a cell can be acquired with a lateral resolution of about 5 nm.
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