Abstract
ABSTRACT BACKGROUND AND OBJECTIVES: Acute and chronic pain is a major problem with repercussion in our society, causing impairment in the quality of life of patients as well as socioeconomic losses, due to work absenteeism. This review aims to analyze the use of tapentadol, an analgesic not yet available in Brazil, with a dual mechanism of action, in the treatment of acute and chronic pain syndromes. CONTENTS: A review about this new drug was made on the Pubmed database using the keywords tapentadol and opioids, evaluating its pharmacological and clinical aspects comparing with other current drugs in pain treatment, as well as its indications and contraindications in the management of patients with pain disorders. CONCLUSION: Tapentadol has been shown to be effective in the treatment of acute and chronic pain, with potency equivalent to the opioids currently used. In addition, it developed less tolerance, less adverse effects and better therapeutic response in chronic neuropathic pain when compared to pure µ-opioid receptors agonists.
Highlights
Pain is a problem of great proportion, involving 20 to 25% of the population with an increasing incidence
The objective of this study was to analyze the use of tapentadol, an analgesic not yet available in Brazil, with a dual mechanism of action, in the treatment of acute and chronic pain syndromes
The most frequent adverse effects reported associated with the continuous opioid therapy are a problem for patients with chronic pain, such as nausea in 6 to 42%, vomit in 8 to 33% and constipation in 3,1 to 95% of patients[18]
Summary
Pain is a problem of great proportion, involving 20 to 25% of the population with an increasing incidence. The objective of this study was to analyze the use of tapentadol, an analgesic not yet available in Brazil, with a dual mechanism of action, in the treatment of acute and chronic pain syndromes.
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