TAP expression in precancerous lesions of colorectal cancer and its significance

Abstract

Objective To investigate the clinical significance of abnormal sugar-chain glycoprotein tumor abnormal protein (TAP) in the screening of common digestive tract pre-cancer colon adenocarcinoma lesions. Methods A total of 50 colitis patients, 50 colon polyp patients and 50 colon adenocarcinoma patients admitted to our hospital from March, 2012 to May, 2014 were included. Fresh blood from the patients' fingertips was collected; and condensation staining was used to detect TAP expression. Results The positive expressions of TAP in the patients with colitis, colon polyp, and colon adenocarcinoma were 6%, 76%, and 92%, with statistical differences (P 0.05). Patient follow-up revealed that the tumor incidences in the TAP-positive patients of the ones with colitis, colon polyp, and colon adenocarcinoma were significantly higher than those in the TAP-negative ones (33.3% vs. 0.0%, 36.8% vs. 8.3%, and 45.0% vs. 10.0%; all P<0.05). Conclusion TAP has a higher expression in colon pre-adenocarcinoma lesions. Additionally, TAP participates in the processes from intestinal mucosal inflammation to colon polyp, and to tissue canceration. Therefore, TAP can be used for the screening of digestive tract precancerous lesions. Key words: Colitis; Colon polyp; Colon adenocarcinoma; Tumor abnormal protein