Abstract
Four new polyketides have been identified in culture filtrates of the fungal strain Penicillium sp. IBWF104-06 isolated from a soil sample. They are structurally based on the same trans-decalinpentanoic acid skeleton as tanzawaic acids A–H. One of the new compounds was found to inhibit the conidial germination in the rice blast fungus Magnaporthe oryzae at concentrations of 25 μg/mL.
Highlights
Nature still represents the richest source of new antimicrobials which can be attractive as lead structures or biochemical tools for target identification for medical applications as well as for crop science
The omnipresent development of resistance results in a demand for new active principles for which the structural diversity of nature holds an excellent supply. Their synthesis, evolution, and ecological role are of academic interest, compounds identified might be relevant for application
In the course of investigations into the secondary metabolism of fungal species for the identification of novel lead structures for agrochemical and pharmaceutical research, we isolated a fungal strain from a soil sample
Summary
Nature still represents the richest source of new antimicrobials which can be attractive as lead structures or biochemical tools for target identification for medical applications as well as for crop science. These spectra showed signals of three CH3 groups, Table 1: 1H NMR data of compounds 1–4 (CD3OD, 600 MHz).
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