Abstract
Purpose: Contrast-enhanced computed tomography (CECT) allows detection of changes in cartilage structure and function via use of a contract agent, which diffuses into cartilage. The aim of this study is to investigate potential of a novel nanoparticle contrast agent for computed tomography (CT) diagnosis of osteoarthritis. An early indicator of cartilage degeneration is the loss of collagens and proteoglycans (PG) leading to enhanced tissue permeability and decreased tissue mechanical integrity.
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