Abstract
Tannin Screening, Phenolic Compounds Analysis, and Antiproliferative Activity of Areca Nut Extract by Decreasing Ki-67 Protein in Oral Squamous Carcinoma Cell Lines
Highlights
Oral Squamous Carcinoma (OSC) is one of the most frequent malignant neoplasms in the oral cavity and about 8% of all malignancies of head and neck cancer worldwide.[1,2] This condition represents more than 90% of the malignancies that occur in the oral cavity.[3]
The current study is aimed at exploring tannin content, analysis of phenolic compounds, and the effect of areca nut extract on the proliferation of OSC cells by assessing the cell-cycle arrest and analysis of Ki-67 activity in HSC-2 and HSC-3 cells after 24 and 48 hours treatment
The areca nut is classified as a dark fruit, our result showed that the areca nut extract contained a small amount of tannin compared to areca nut from various districts in Karnataka, India (1.13–3.39% tannin).[31]
Summary
Oral Squamous Carcinoma (OSC) is one of the most frequent malignant neoplasms in the oral cavity and about 8% of all malignancies of head and neck cancer worldwide.[1,2] This condition represents more than 90% of the malignancies that occur in the oral cavity.[3]. If the damage is detected in the checkpoint, the cell will pause and subscribe to the checkpoint to make repairs.[12] If the damage can be repaired the cell continues DNA complete replication, but if not, the cell may undergo apoptosis This doesn't occur in cancer cells that will continue to replicate despite cell damage. Studies which explained the association between areca nut extract and its ability to inhibit cancer cell function have not been widely conducted. The current study is aimed at exploring tannin content, analysis of phenolic compounds, and the effect of areca nut extract on the proliferation of OSC cells by assessing the cell-cycle arrest and analysis of Ki-67 activity in HSC-2 and HSC-3 cells after 24 and 48 hours treatment
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