Tank Circuit for Ultrafast Single-Particle Detection in Micropores.

Abstract

We present an ultrafast single submicron particle detection method based on a half-bowtie coplanar waveguide. The method is capable of resolving the translocation of these particles at a bandwidth greater than 30MHz. We compare experimentally the simultaneous use of our radio-frequency technique with conventional dc based resistive pulse recordings and find that our method has a throughput that is enhanced by 2 orders of magnitude. The technique incorporates a microfluidic circuit and has the potential to be employed for screening microparticles and biological cells at frequencies in excess of 1GHz.