Abstract
A major advance in the treatment of high-risk patients with solid tumors has been to intensify therapy. We hypothesize that the use of tandem high dose chemotherapy followed by stem cell rescue will improve survival in children with high-risk solid tumors. Fifteen patients were enrolled from March 2000 to August 2004 with a median age of 6 years (2–19). Each had received at least 2 courses of chemotherapy prior to study enrollment. Patients (Table 1) had the following diagnoses: recurrent Wilms tumor (n = 5), high-risk Ewing’s sarcoma (n = 3), recurrent hepatoblastoma (n = 2), recurrent retinoblastoma (n = 2), recurrent germ cell tumor (n = 2), and undifferentiated sarcoma (n = 1).
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