Abstract
Accurate analysis of organophosphate pesticides (OPs) with portable devices remain an elusive goal that have received widespread investigative attention in the areas of environmental contamination and disease prevention. Herein, using all-in-one enzyme-inorganic hybrid nanoflowers (ACC-HNFs) to fabricate high-performance artificial enzyme cascade system, we established a sensitive and affordable lab-on-paper biosensor. This biosensor incorporated disposable screen-printed carbon electrode (SPCE) and colorimetric test strips, which enabled the dual-modal readout (electrochemical and colorimetric signal) for on-site monitoring of OPs, achieving an “on-demand” tuning of the detection performance. Using paraoxon as a model analyte, the ACC-HNFs-based lab-on-paper platform could reach a limit of detection down to the femtogram/mL level (6 fg mL−1). Meticulous design of ACC-HNFs provided a versatile approach for constructing artificial enzyme as a recognizer and amplifier to fill the gap in constructing robust artificial enzyme systems which can be used for on-site contamination monitoring and biological diagnosis.
Published Version
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