Abstract
AbstractThe asymmetric synthesis of tetracyclic pyrroles bearing a tetrasubstituted carbon stereocenter has been accomplished through a one‐pot sequence that comprises a cross metathesis reaction followed by a tandem cycloisomerization/ intramolecular Pictet‐Spengler‐type reaction. This sequence took place on conveniently functionalized chiral amino acids to render the final products in good overall yields and diastereoselectivities up to 20:1. Those pyrrole‐containing scaffolds are present in a variety of biologically relevant compounds.magnified image
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