Tanacetum parthenium relieves chronic constriction injury-induced neuropathic pain in male rats

Abstract

Background: Neuropathic pain is a chronic developing pain due to injury or disease-involving somatosensory systems such as vascular disorders, autoimmune diseases, inflammation, and traumatic injuries. Herbal medicines were utilized for the treatment of various diseases too late. The aim of this study was to evaluate the effect of Tanacetum parthenium (TP) extract on chronic constriction injury (CCI)-induced neuropathic pain. Materials and Methods: In the present study, 48 adult male Wistar rats weighing 200–250 g were used. After anesthetizing the animals, CCI was performed on the left sciatic nerve for inducing neuropathic pain. TP extracts were intragastrically administered daily for 2 weeks by a gavage tube. Mechanical allodynia and thermal hyperalgesia were assessed using Von Frey hairs and plantar test device, respectively. The data were analyzed using the one-way analysis of variance and Tukey's post hoc test. Results: CCI led to mechanical allodynia and thermal hyperalgesia. TP extract with higher doses used in this study significantly increased (P