Tamra Bhasma preparation by two methods and evaluating their effect on the Liver Function test pre-clinically

Abstract

Rasashastra is an important branch of Indian System of Medicine, which deals with the pharmaceutical processes, such as preparations of Bhasmas, Pistis, Kharaliya Rasayanas, Druti, Kupipakva Rasayanas, Parpati, Pottali. It is a well-known fact in the Ayurveda world that Bhasmas are highly efficacious and there are so many preparations of Tamra that are indicated for different ailments. Medicines (kalpas) mentioned in Rasa shastra are used freely in clinical practice by Ayurveda physicians after trial and testing. Now Ayurveda is accepted by world. Due to globalization, it is necessary to prove the Ayurveda drugs with modern parameters. So it can be utilized worldwide to get health. Hence the work taken here is preparation of Tamra Bhasma by two different methods and evaluating their effect on the Liver Function test pre-clinically. Tamra Bhasma preparation by two methods was chosen to compare the difference between direct heat and indirect heat method. Preparation with indirect heat by using sunlight method and with direct heat method resulted into bhasma. Biochemical and Histopathological changes in Liver were observed. Liver function assessment parameters namely serum Bilirubin, SGOT, SGPT, total protein were taken for biochemical evaluation. Also histopathology of Liver and Kidney was taken for study in support of biochemistry. The results were compared with standard drug Silymarine.