Abstract
As drug delivery systems Nanoparticulate widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. So, Solid Lipid Nanoparticles have recently received considerable attention as alternative drug delivery carrier. In this study Solid Lipid Nanoparticles (SLNs) containing tamoxifen, nonsteroidal antiestrogens have been loaded and to be used as breast cancer therapy, were prepared by hot High Pressure Homogenization techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. Preliminary study of antiproliferative activity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration. SLN was characterized by Differential Scanning Calorimetery (DSC), Transmission Electron Microscopy (TEM), Zeta Potential and Particle Size. The results of characterization studies strongly support the potential application of Tamoxifen-loaded SLNs as a carrier system. The SLN presented here are well suited for certain drug delivery applications, particularly breast cancer therapy.
Highlights
It has become more and more evident that the development of new drugs alone was not sufficient to ensure progress in drug therapy
Cytotoxicity activity and drug loading capacity: Cytotoxicity of tamoxifen from nanoparticles was assessed against MCF-7 cells
Cytotoxicity activity and drug loading capacity: It is believed that formulating tamoxifen with Solid Lipid Nanoparticles (SLNs) could be advantageous to other colloidal or polymeric material due to the lack of toxicity of amphiphilic tamoxifen against fibroblasts and polymorphonuclear cells
Summary
It has become more and more evident that the development of new drugs alone was not sufficient to ensure progress in drug therapy. A promising strategy to overcome these problems involves the development of suitable drug carrier systems. The SLNs combined the advantages of other innovative carrier systems (e.g., physical stability, protection of incorporated labile drugs from degradation, controlled release and excellent tolerability) while at the same time minimizing the associated problems. Lipophilic drugs, with good compatibility with the lipids, have often been selected to incorporate into the SLNs for high drug loading and entrapment efficiency[1,15,17]. The high pressure homogenization technique has emerged as a reliable and powerful technique for preparation of SLNs. In contrast to other techniques, scaling up represented no problem in most cases.
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