Abstract
Magnetic iron oxide containing MCM-41 silica (MM) with ~300 nm particle size was developed. The MM material before or after template removal was modified with NH2- or COOH-groups and then grafted with PEG chains. The anticancer drug tamoxifen was loaded into the organic groups’ modified and PEGylated nanoparticles by an incipient wetness impregnation procedure. The amount of loaded drug and the release properties depend on whether modification of the nanoparticles was performed before or after the template removal step. The parent and drug-loaded samples were characterized by XRD, N2 physisorption, thermal gravimetric analysis, and ATR FT-IR spectroscopy. ATR FT-IR spectroscopic data and density functional theory (DFT) calculations supported the interaction between the mesoporous silica surface and tamoxifen molecules and pointed out that the drug molecule interacts more strongly with the silicate surface terminated by silanol groups than with the surface modified with carboxyl groups. A sustained tamoxifen release profile was obtained by an in vitro experiment at pH = 7.0 for the PEGylated formulation modified by COOH groups after the template removal. Free drug and formulated tamoxifen samples were further investigated for antiproliferative activity against MCF-7 cells.
Highlights
Mesoporous silicas are promising drug carriers because of their beneficial textural characteristics, such as uniform pores with controllable size, large pore volume, high specific surface area (>700 m2 /g), and good chemical and thermal stability [1,2,3]
Our results showed that tamoxifen molecule interacts more strongly with the silicate surface terminated by silanol groups compared to the one modified with CH2 COOH groups, as the binding energy (BE) values for the most stable complexes in both cases are −279 kJ/mol and −184 kJ/mol, respectively
The pore surface of the material was functionalized by incorporation of NH2 and -COOH groups and further PEGylated
Summary
Mesoporous silicas are promising drug carriers because of their beneficial textural characteristics, such as uniform pores with controllable size, large pore volume, high specific surface area (>700 m2 /g), and good chemical and thermal stability [1,2,3]. Mesoporous silica nanoparticles have been used for the delivery of a wide variety of chemotherapeutic and bioimaging agents owing to their unique characteristics and tailored methods of preparation. A drawback of the conventional drug delivery carriers used in oncology is their inability to control the release rate and simultaneously provide site-specific delivery. The modification of magnetic nanoparticles or 2their
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