Abstract
Previous authors have separately reported that the hyperreactivity syndrome commonly found after septal lesion can be attenuated by injection of either a serotonin depletor, PCPA, or a serotonin precursor, 5-HTP. The present experiment used a factorial design to investigate these apparently discrepant results. As previously reported, each drug produced a taming effect in septal animals, and additionally, the combination of the two drugs tended to have an additive, rather than an antagonistic, effect. This suggests that the two drugs might share a common neurochemical action. Since Sloviter, Drust, and Connor (1978) have reported that PCPA has an early serotonin-releasing effect, it appears that serotonin release, not depletion, has a taming effect in septal animals.
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