Abstract
Breast carcinomas are a heterogeneous group of malignancy, having variable clinical outcomes depending on their cellular and molecular properties. Tall cell carcinoma with reverse polarity (TCCRP) is a recently described rare entity, which shares morphological features with tall cell variant of papillary thyroid carcinoma but has a distinct morphological, immunohistochemical, and molecular profile. We describe a case of a 40-year-old female patient, who presented with lump in the breast. The patient underwent lumpectomy and was diagnosed as tall cell carcinoma with reverse polarity. Immunohistochemistry and bi-directional Sanger sequencing for IDH2 mutation were used for diagnosis. Tall cell carcinoma with reverse polarity is a rare and newly described entity with characteristic morphological and molecular findings, which carries an excellent prognosis.
Highlights
Tall cell carcinoma with reverse polarity (TCCRP) is a rare type of invasive breast carcinoma with characteristic immuno-morphologic and molecular findings and is often difficult to diagnose
We are presenting a case report of this rare entity in a 40-year-old female, currently named “Tall cell carcinoma with reverse polarity” by the World Health Organization [6] and there are only scattered case reports and very few case series published in the world literature to the best of our knowledge
Tall cell carcinoma with reverse polarity is a recently described invasive breast carcinoma, included in the 5th edition of WHO classification of breast tumors as a slowgrowing tumor with favorable prognosis [1,2,3,4,5,6]. These tumors most commonly occur in women around the age of 65 years, with characteristic immuno-morphologic features
Summary
Tall cell carcinoma with reverse polarity (TCCRP) is a rare type of invasive breast carcinoma with characteristic immuno-morphologic and molecular findings and is often difficult to diagnose. In 2003, reported a rare variety of breast carcinoma having features similar to papillary thyroid carcinoma described as “Breast tumor resembling the tall cell variant of papillary thyroid carcinoma” [1]. These tumors were called breast tumor resembling the tall cell variant of papillary thyroid carcinoma; solid papillary breast carcinoma resembling tall cell variant of papillary thyroid carcinoma; solid papillary carcinoma with reverse polarity [1,2,3,4,5]. E) Follicular structures with eosinophilic/amphophilic colloid-like secretions (H&E; x100)
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