Abstract
Talaromynoids A-E (1-5), five new fusicoccane diterpenoids, were obtained from the endophytic fungus Talaromyces sp. DC-26, which was isolated from a wild leech. Talaromynoid A (1) represents the first fusicoccane diterpenoid bearing an unexpected 5-7-5 tricyclic ring system, which is possibly derived from normal 5-8-5 ones by ring contraction. Talaromynoid E (5) is characterized by an unusual oxygen bridge between C-1 and C-8 that establishes the eight-membered ring B to be a 9-oxo-bicyclo[3.3.1]nonane. Structures of 1-5 with absolute configurations were determined by extensive NMR spectral analyses, electronic circular dichroism (ECD) calculations, X-ray diffraction analyses, and acid hydrolysis.
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