Abstract
Emerging Infections Arthropods are the most abundant animals on Earth and can transmit diseases such as dengue or West Nile virus to humans. Bryden et al. tried to manipulate the immune reaction at the site of mosquito bites to restrict viral dissemination. They found that local Toll-like receptor 7 (TLR7) activation shortly after infection dampened replication of a model alphavirus in mice. This held true for clinically relevant arboviruses and in human skin explants. Viral restriction was due to activation of skin macrophages and heightened type I interferon production. Topical TLR7 activation after mosquito bites could be a broad-acting approach to abrogate arboviruses. Sci. Transl. Med. 12 , eaax2421 (2020).
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