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Abstract
Dietary therapy is the mainstay of treatment for diabetes. This study examined the effect of a low glycemic index (GI) multi-nutrient supplement, consumed in place of breakfast, on glycemic control in patients with type 2 diabetes mellitus (T2DM). A total of 71 participants were randomized at a 2:1 ratio into either a breakfast replacement group or a normal breakfast group for a 12-week interventional study. The primary outcome measure was change in hemoglobin A1c (HbA1c). Nutrition status and somatometry were studied as secondary outcomes. The breakfast replacement group displayed a −0.2% absolute reduction in HbA1c (95% CI (confidence interval), −0.38% to −0.07%, p = 0.004), while the HbA1c of the control group increased 0.3% (95% CI, 0.1% to 0.5%, p = 0.005). The baseline Mini Nutritional Assessment score for both groups was 26.0 and no significant changes occurred following intervention. However, there was a statistically significant difference in body mass index between the treatment and control groups (p = 0.032) due to the weight gain in the control group (increased 0.5 kg, 95% CI was 0.2 to 0.9, p = 0.007). These data suggest that breakfast replacement with a low GI multi-nutrient supplement can improve glycemic and weight control in T2DM.
Highlights
Type 2 diabetes mellitus (T2DM) is a chronic progressive metabolic disorder characterized by hyperglycemia and glucose intolerance [1]
The inclusion criteria were as follows: subjects had to be diagnosed with type 2 diabetes mellitus (T2DM) according to the American Diabetes Association (ADA) criteria for the diagnosis of diabetes [11], between 18 and 75 years old, and had a body mass index (BMI) of >18.5 kg/m2 and
The goal of this study was to evaluate the potential effect of the multi-nutrient supplement as a low glycemic index (GI) breakfast on glycemic control in T2DM patients
Summary
Type 2 diabetes mellitus (T2DM) is a chronic progressive metabolic disorder characterized by hyperglycemia and glucose intolerance [1]. It leads to numerous and varied complications, such as in the cardiovascular, nervous and urinary systems, and is the seventh leading cause of death in 2010 according to the World Health Organization [2]. The incidence of T2DM has almost doubled during the past three decades [3,4]. In China, there is a widespread occurrence of T2DM with an overall prevalence estimated by a report published in 2013 at 11.6% of the total population, 12.1% of men and 11.0% of women [5]. Hyperglycemia is thought to be effectively controlled by medication and lifestyle interventions
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