Abstract
Vitamin C is essential for wound healing. However, there are no reports concerning the effect of a different dose of vitamin C on extraction wound size clinically. Therefore, the aim of this study was to investigate the effect of different oral vitamin C doses on extraction wound healing. A split-mouth, double-blind randomized clinical trial was performed in 42 patients who underwent symmetric bilateral noninfected premolar extraction. The patients were randomly divided into 3 groups, namely, P/600, P/1,500, and 600/1,500 (14 patients for each group); P/600: placebo vs. 600 mg vitamin C/d, P/1,500: placebo vs. 1,500 mg vitamin C/d, and 600/1,500: 600 mg vitamin C/d vs. 1,500 mg vitamin C/d. Patients were prescribed placebo or/and vitamin C three times a day for 10 days after each tooth extraction. Extraction wound size and pain score were evaluated. The wound assessment was performed on day 0, 7, and 21; and then the tooth on the other side was extracted using the same protocol. Pain score was recorded on the first three days after extraction. The reduced size of mesiodistal extraction wound in percentage reduction between day 0 and 7 of teeth receiving vitamin C 600 mg/d was more than that in placebo (P < 0.05). Pain scores on day 1–3 of teeth receiving vitamin C 600 mg/d were significantly lower than the placebo side (P < 0.05). Taking oral vitamin C 600 mg/d over three doses for 10 days after tooth extraction enhances extraction wound healing by reducing mesiodistal extraction wound and reduces postoperative pain.
Highlights
Wound healing has been studied for decades, the wound healing process after tooth extraction is still not fully understood
Delayed wound healing is a failure to progress through the normal phases and nutritional deficiencies, such as vitamin C that humans have to obtain from their diet, which is a significant factor in all phases of wound healing [3]
BL, MD, and socket depth, of extraction wound healing related to vitamin C supplementation and wound size measurement was performed to provide reliable objective data
Summary
Wound healing has been studied for decades, the wound healing process after tooth extraction is still not fully understood. Tooth extraction is a common dental procedure, there are common minor postoperative complications, such as delayed wound healing that impacts patients’ quality of life and increases clinical workload and cost [1]. E wound healing process requires both macronutrients and micronutrients [2, 3]. Delayed wound healing is a failure to progress through the normal phases and nutritional deficiencies, such as vitamin C that humans have to obtain from their diet, which is a significant factor in all phases of wound healing [3]. Vitamin C is required for neutrophil apoptosis and clearance. There are few clinical studies in humans, especially concerning oral wound healing [9–11].
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