Abstract

Acting through cannabinoid receptors, endogenous endocannabinoids (eCBs), such as anandamide, modulate pain and anxiety, among other things; substances that inhibit enzymes that break down eCBs may have antianxiety properties. Because cyclooxygenase-2 (COX-2), which catalyzes synthesis of prostaglandins from arachidonic acid, also inactivates anandamide, researchers explored the …

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