Abstract

Before engaging G protein-coupled receptors (GPCRs) to transduce extracellular signals, heterotrimeric Gproteins (Gαβγ) must fold properly with the help of chaperones. In this issue of Structure, Papasergi-Scott etal. (2023) unveil the molecular basis for how mammalian Ric-8 chaperones achieve selectivity for their respective Gα subunit clients.

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