Abstract
Graft copolymers of chitosan were prepared using acrylic and methacrylic acids. The grafting was initiated by eerie ion. Experimental parameters such as the concentrations of monomer and the initiator on grafting were investigated. The percent grafting, grafting efficiency and percent conversion of the monomer were also analysed. The graft copolymers were further characterized by infrared spectroscopy and gravimetric analysis. These graft copolymers were subsequently utilized for the preparation of functionalized chitosan beads by a polymer dispersion technique. The morphological characteristics were studied by optical and scanning electron microscopy. Particle size analysis was also carried out. Sulphadiazine was entrapped in the microspheres and the in vitro drug release profiles were established both in simulated gastric and intestinal fluids.
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