Abstract
Titanium-based alloys are known as a “gold standard” in the field of implantable devices. Mg-based alloys, in turn, are very promising biocompatible material for biodegradable, temporary implants. However, the clinical application of Mg-based alloys is currently limited due to the rapid resorption rate in the human body. The deposition of a barrier layer in the form of bioactive calcium phosphate coating is proposed to decelerate Mg-based alloys resorption. The dissolution rate of calcium phosphates is strongly affected by their crystallinity and structure. The structure of antibacterial Cu- and Zn-substituted hydroxyapatite deposited by an radiofrequency (RF) magnetron sputtering on Ti and Mg–Ca substrates is tailored by post-deposition heat treatment and deposition at increased substrate temperatures. It is established that upon an increase in heat treatment temperature mean crystallite size decreases from 47 ± 17 to 13 ± 9 nm. The character of the crystalline structure is not only governed by the temperature itself but relies on the condition such as either post-deposition treatment, where an amorphous calcium phosphate undergoes crystallization or instantaneous crystalline coating growth during deposition on the hot substrate. A higher treatment temperature at 700 °C results in local coating micro-cracking and induced defects, while the temperature of 400–450 °C resulted in the formation of dense, void-free structure.
Highlights
Medical devices are an inherent part of modern medicine. the constant demand for new, prospective implants is caused by global population aging [1]. the total number of patients worldwide subjected to the risk of bone fracture has been projected to double in 2040 [2]
We studied the influence of the substrate temperature on the formation of crystalline Zn-HA coating, when trying insight into the crystalline structure formation during magnetron deposition as a function of adatom mobility
The effect of post-deposition heat treatment vs. coating deposition at increased substrate temperatures on crystallization and surface morphology of the Cu and Zn containing calcium phosphates (CaP) on Mg–Ca and Ti alloys deposited by an RF magnetron sputtering was studied
Summary
Medical devices are an inherent part of modern medicine. the constant demand for new, prospective implants is caused by global population aging [1]. the total number of patients worldwide subjected to the risk of bone fracture has been projected to double in 2040 [2]. The constant demand for new, prospective implants is caused by global population aging [1]. The total number of patients worldwide subjected to the risk of bone fracture has been projected to double in 2040 [2]. Titanium (Ti) based alloys remain the most widely used materials for permanent implants when treating bone. Ti-based alloys are well studied and frequently being classified as the “gold standard”. In metallic implants in both orthopaedic and dental areas. It is documented that under the influence of mechanical stress-protective TiO2 layer could be disturbed and metallic particle leakage could be the reason for various adverse reactions in host tissue [3]. Magnesium (Mg) based alloys, are very promising biocompatible materials for biodegradable, temporary implants [4].
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