Abstract
Not to clot: Heparin and its low-molecular-weight derivatives are clinical therapeutics used to treat and prevent blood clots. The synthesis of heparin-based glycopolymers that are potent and potentially safer mimetics of heparin is described. The mimetics exhibited activity against proteases (FXa and FIIa) in the coagulation cascade and prolonged blood clot times in human plasma with efficacies similar to those of clinical anticoagulants. ATIII=antithrombin III.
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