Abstract
The diurnal rhythm of total acid phosphatase and prostatic phosphatase activities was investigated in patients with prostate carcinoma. In these patients, the activities of total acid phosphatase, the tartrate-sensitive fraction of acid phosphatase, and lactate dehydrogenase decrease after therapy, whereas the activity of alkaline phosphatase increases. In all patients with prostate carcinoma, the total and tartrate-inhibited acid phosphatase, and the level of cortisol show a diurnal rhythm before therapy, with a minimum at night. In one patient, after orchiectomy, the cortisol rhythm remained unchanged, but the daily phosphatase variation was absent. Diurnal variations of lactate dehydrogenase and alkaline phosphatase were also observed in 2 patients without prostate carcinoma, but with elevated levels of these enzymes.
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