Abstract
The micro-particles composed of different chemical elements potentially can be used to yield the multi-element code for labeling of the molecules of interest. Proposed approach can recognize numerous analytes (biomarkers of diseases) of interest in parallel with minimum interfering. We report on a Laser Induced Breakdown Spectroscopy analysis of samples with known and controlled ratio of concentration of three metallic, two tags and a substrate, micro-particles, containing one of the chemical elements Ti, Si and Fe, as a function of the load of a particular element in a single or binary target sample. In addition, we report on the detection of ovarian cancer biomarker leptin in PBS buffer with 5% BSA using two metal micro-particles as Tags for LIBS with magnetic particle separation. We also show that the dual-TAG LIBS approach yields a 1.3 to 10 times enhancement in signal response obtained by the dual- over the single elemental marker approach.
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