TAFI antigen level variability in young healthy Asian Indians; First report from Asia

Abstract

Thrombin Activatable Fibrinolytic Inhibitor (TAFI) is a plasma protein, which inhibits fibrinolysis by removing carboxyterminal lysine residues from partially degraded fibrin thereby decreasing plasminogen binding on its surface. In this study we have investigated the antigenic level variability (Inter and Intraindividual) of Thrombin Activatable Fibrinolysis Inhibitor in 120 healthy Asian Indians since no data on this is available regarding this population. TAFI antigen levels did not show a normal distribution in our population ( p < 0.001). Median TAFI antigen levels were found to be 11.683 µg/ml. It ranged from 33.9–202.5%of normal pool plasma (3.9–23.5 µg/ml). TAFI antigenic level showed high level of variability in the Indian population (coefficient of variation: 37.4%). TAFI antigenic levels were stable intraindividually ( p = 0.218).