Abstract
Tacrine based reversible inhibitors of cholinesterases (ChEIs) containing peptidic tethers were synthesized to interact with specific regions at the gorge level, and their potency was determined with human ( h) acetylcholinesterase and butyrylcholinesterase. Analogues 3i, j and 3l, m were identified as promising hits and may pave the way for the development of a new series of tacrine based enzyme selective hChEIs.
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