Abstract
BackgroundThe tachykinin receptor 2 (TACR2) is encoded by the tachykinin receptor correlation gene. Recent microarray analysis for prostate cancer suggests that TACR2 expression is associated with clinical phenotype and disease-free survival among patients with prostate cancer.ResultsTACR2 protein levels were lower in prostate cancer tissues than in adjacent normal prostate tissue. TACR2 expression significantly correlated with clinical stage, Gleason scores, and survival outcomes. TACR2 expression positively correlated with mast cells and negatively correlated with M2 macrophages. Overexpression of TACR2 promoted the migration and proliferation of prostate cancer cells by regulating the Wnt signaling pathway.ConclusionsThe TACR2-Wnt/β-catenin signaling pathway is critical in prostate cancer. TACR2 may affect tumor cells’ occurrence and development by changing the content of immune cells in the tumor microenvironment. These findings suggest that TACR2 may be a candidate molecular biomarker for prostate cancer therapy.
Highlights
The tachykinin receptor 2 (TACR2) is encoded by the tachykinin receptor correlation gene
We found that TACR2 may affect the migration and proliferation of prostate cancer cells by regulating the Wnt/β-catenin signaling pathway. These findings suggest that TACR2 may be used as a marker of prostate cancer development and may become a potential therapeutic target
TACR2 was downregulated in tumor tissue To explore the expression pattern of TACR2, we used the TIMER database to determine that TACR2 expression was significantly downregulated in a variety of cancer tissues
Summary
The tachykinin receptor 2 (TACR2) is encoded by the tachykinin receptor correlation gene. Recent microarray analysis for prostate cancer suggests that TACR2 expression is associated with clinical phenotype and disease-free survival among patients with prostate cancer. Prostate cancer is the second most common malignant tumor in men and the fifth most common cause of cancer death worldwide. Its mortality has decreased in recent years, more than 300,000 men still die of prostate cancer every year; especially in developed countries, prostate cancer prevalence remains very high [1,2,3]. Prostate-specific antigen (PSA) is a kallikrein-like serine protease secreted by prostatic epithelial cells. Its serum expression levels can be used to screen for prostate cancer. The utility of PSA is limited and controversial [4,5,6].
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