Abstract
Background: This study aimed to assess the factors contributing to the outcomes of recently hospitalized patients with heart failure (HF).Methods: A prospective data of 76 adults who were admitted due to acute HF between October 1, 2019 and June 30, 2020 at our center were analyzed. Endpoints included survival and rehospitalization within six months after discharge.Results: The mean age was 64.9 ± 13.8 years, with a male preponderance (68.4%). Approximately 60.5% of patients had the left ventricular ejection fraction (LVEF) <40%, whereas 26.3% of patients had LVEF ≥50%. Coronary artery disease (75%), arterial hypertension (72.4%), chronic kidney disease (46.1%), and diabetes mellitus (46.1%) were the most frequent comorbidities. Poor compliance (40.8%) and non-cardiac infection (21.1%) were the common precipitating factors for hospitalization. The majority of subjects had severe symptoms, indicated by the frequent need of intensive care unit (43%), high N-terminal prohormone brain natriuretic peptide levels [NT-proBNP; median, 4765 (1539.7-11782.2) pg/mL], and presence of either atrial fibrillation, severe mitral regurgitation, or significant pulmonary hypertension in approximately one-third of cases. Even though in-hospital mortality was relatively low (2.6%), the all-cause mortality and rehospitalization rates in the next six months after discharge were still high, reaching 22.54% and 19.72%, respectively. Further survival analysis showed that tachycardia on admission and pre-existing chronic kidney disease (CKD) resulted in low six-month survival rates among these patients.Conclusion: After hospital discharge, patients with HF were still exposed to higher risks of death and readmission albeit with the medication addressed. Tachycardia on admission and pre-existing CKD might predict worse outcomes.
Highlights
Heart failure (HF) is a major global problem and the leading cause of morbidity and mortality worldwide [1]
Further survival analysis showed that tachycardia on admission and pre-existing chronic kidney disease (CKD) resulted in low six-month survival rates among these patients
This study aimed to describe the clinical characteristics and analyze the essential factors contributing to outcomes of hospitalized patients with Acute HF (AHF)
Summary
Heart failure (HF) is a major global problem and the leading cause of morbidity and mortality worldwide [1]. HF is the primary reason for hospitalization in the elderly population, and the number of readmissions is high in this population at risk [2]. These data showed that HF is a crucial issue and challenge for health services in the community. Patient-based, rather than disease-based, data might provide essential information to evaluate miscellaneous aspects of hospitalized patients with AHF [5,6]. This approach could improve the clinical assessment and management strategy to reduce in-hospital mortality and rehospitalization rates caused by AHF. This study aimed to assess the factors contributing to the outcomes of recently hospitalized patients with heart failure (HF)
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